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Circulating levels of placental protein 14 in ectopic pregnancy
Author(s) -
Stabile I.,
Olajide F.,
Chard T.,
Grudzinskas J. G.
Publication year - 1994
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1994.tb11942.x
Subject(s) - miscarriage , medicine , ectopic pregnancy , obstetrics , pregnancy , vaginal bleeding , abortion , gynecology , missed abortion , recurrent miscarriage , fetus , genetics , biology
Objective To determine circulating levels of placental protein 14 (PP14) in complications of early pregnancy. Design Biochemical monitoring of women presenting with vaginal bleeding and/or abdominal pain. Setting An emergency gynaecological ultrasound clinic in a London teaching hospital. Subjects Venous blood samples were obtained from 67 women with normal pregnancy ( n = 9 ), ectopic pregnancy ( n = 26 ) and failed intrauterine pregnancy ( n = 32 ). This group included anembryonic pregnancy ( n = 18 ), missed miscarriage ( n = 2 ), spontaneous miscarriage of a previously demonstrated live fetus ( n = 6 ), incomplete miscarriage ( n = 4 ), complete miscarriage ( n = 1 ) and molar pregnancy ( n = 1 ). Main outcome measures Serum PP14 levels in the group of women with a failed intrauterine pregnancy in relation to the normal range for PP14. Results Eighty‐one percent of women who miscarried spontaneously had normal serum PP14 levels; 81% of women with ectopic pregnancy had depressed (< 5th centile) serum PP14 levels. Conclusion Measurements of PP14 may be useful in distinguishing spontaneous miscarriage from ectopic pregnancy, but not in the management of threatened miscarriage.