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Fetal immunological and haematological changes in intrauterine infection
Author(s) -
Thilaganathan Baskaran,
Carroll Steve G.,
Plachouras Nicholas,
Makrydimas George,
Nicolaides Kypros H.
Publication year - 1994
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1994.tb11915.x
Subject(s) - neutrophilia , fetus , immunology , lymphocytosis , gestation , lymphocyte , medicine , biology , pregnancy , physiology , genetics
Objective To study fetal immunological and haematological changes to intrauterine infection. Design In 37 pregnancies at risk of intrauterine infection, fetal blood obtained by cordocentesis at 20 to 36 weeks gestation was used for differential leucocyte counts, platelet count, enumeration of lymphocyte subpopulations, and neutrophil adhesion receptor expression. Setting Harris Birthright Research Centre for Fetal Medicine, London. Results All four fetuses with viral infections had platelet counts below the 5th centile and three had natural killer (NK) cell counts greater than the 95th centile of the normal range. Similarly, all five fetuses with bacterial or candidal infection had neutrophil counts greater than the 95th centile of the normal range; lymphocyte subpopulations were normal. Conclusions In pregnancies complicated by intrauterine infection, fetuses exhibit NK cell lymphocytosis and thrombocytopenia in response to viraemia, and neutrophilia in response to bacteraemia from at least 21 weeks gestation.