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Levels of insulin‐like growth factor‐I and insulin‐like growth factor‐binding protein‐1 in pregnancy with preterm delivery
Author(s) -
Wang HsinShih,
Lee Cheng L.,
Chard Tim
Publication year - 1993
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1993.tb15275.x
Subject(s) - medicine , pregnancy , insulin like growth factor , gestational age , insulin like growth factor binding protein , radioimmunoassay , insulin , obstetrics , gestation , preterm delivery , singleton , growth factor , endocrinology , biology , receptor , genetics
Objective To investigate the relationship between preterm delivery and maternal serum insulin‐like growth factor‐I (IGF‐I) and insulin‐like growth factor‐binding protein‐1 (IGFBP‐1) levels. Design A study over a 12 month period in which all samples were collected according to a pre‐set protocol. Setting St. Bartholomew's Hospital, London. Subjects Thirty‐eight nonpregnant adult females, 456 pregnant women at various gestational ages, 84 women with average‐for‐gestational‐age babies at term delivery, and 49 pregnant women with preterm delivery (44 with singleton pregnancy and five with twin pregnancy). Main outcome measures Serum IGF‐I and IGFBP‐1 levels were determined by radioimmunoassay. Results Serum IGF‐I concentrations increased as pregnancy progressed. In the third trimester, serum IGF‐I levels in singleton preterm deliveries were lower than those in normal pregnancies, and IGFBP‐1 concentrations were higher than those in normal pregnancies. This phenomenon was not obvious in the second trimester. Maternal circulating IGFBP‐1 levels were correlated inversely with birthweight in women with singleton preterm delivery. Conclusions Neither IGF‐I nor IGFBP‐1 appears to play a significant role in preterm delivery since maternal serum IGF‐I and IGFBP‐1 levels are similar in preterm and term deliveries.