Premium
An alternative to hysterectomy? GnRH analogue combined with hormone replacement therapy
Author(s) -
Gangar Kevin F.,
Stones R. William,
Saunders Dawn,
Rogers Vera,
Rae Toni,
Cooper Susan,
Beard Richard W.
Publication year - 1993
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1993.tb12980.x
Subject(s) - medicine , goserelin , medroxyprogesterone acetate , visual analogue scale , hormone replacement therapy (female to male) , pelvic pain , hypoestrogenism , estradiol valerate , hysterectomy , urology , medroxyprogesterone , gynecology , menopause , estrogen , surgery , breast cancer , cancer , testosterone (patch)
Objective To assess whether GnRH analogues are effective in relieving pelvic pain and congestion and whether menopausal symptoms caused by GnRH analogues can be minimised by supplementation with low dose continuous combined hormone replacement therapy (HRT). Design Open prospective study. Setting Tertiary referral clinic at a teaching hospital. Patients Twenty‐one women with chronic pelvic pain. Intervention Four months’ therapy with goserelin 3.6 mg/month combined with continuous oestradiol valerate 1 mg daily and medroxyprogesterone acetate 5 mg daily. Main outcome measures Visual analogue scale for pain, menopausal symptoms, bleeding patterns, uterine area, endometrial status, oestradiol concentrations and venogram scores. Results Amenorrhoea was maintained in all but two women. Endometrial atrophy was maintained despite HRT supplementation. Two women had moderate menopausal symptoms but none had severe symptoms. Significant reduction of uterine cross sectional area was maintained throughout the study. There was no significant relief of pain. Conclusions HRT supplementation of GnRH analogues abolishes menopausal symptoms and thus may improve patient acceptability. Potentially beneficial effects such as endometrial atrophy, reduction of uterine volume and amenorrhoea were not negated by HRT. This combination is not effective in the treatment of chronic pelvic pain and congestion.