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Lung volume measured by functional residual capacity in infants following first trimester amniocentesis or chorion villus sampling
Author(s) -
THOMPSON PETER J.,
GREENOUGH ANNE,
NICOLAIDES KYPROS H.
Publication year - 1992
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1992.tb13785.x
Subject(s) - amniocentesis , medicine , respiratory distress , chorionic villus sampling , obstetrics , incidence (geometry) , pregnancy , functional residual capacity , gestation , lung , fetus , lung volumes , prenatal diagnosis , gynecology , surgery , biology , genetics , physics , optics
Objective To determine the incidence of respiratory problems and lung volume abnormalities in babies bom after first trimester amniocentesis or chorion villus sampling. Design A prospective randomized study. Setting Harris Birthright Research Centre for Fetal Medicine, Paediatric Respiratory Laboratory, King's College Hospital. Subjects Babies of mothers who had undergone first trimester amniocentesis ( n = 74 ) or chorion villus sampling (CVS) ( n = 86 ) for fetal karyotyping because of advanced maternal age, parental anxiety or family history of chromosomal abnormal ‐ity in the absence of parental chromosome re‐arrangement. Main outcomes Respiratory distress in the neonatal period and lung volume as assessed by measurement of functional residual capacity (FRC). Results CVS was associated with a significantly higher incidence of neonatal respiratory distress, six infants in the CVS group but none in the amniocentesis group required admission to the special care baby unit because of respiratory distress ( P <0–05 ). Although there was no significant difference in the mean FRC between the two groups (amniocentesis 29–7 ml/kg vs CVS 29–6 ml/kg) the overall incidence of FRC values <2–5th centile of the normal range was 9%. Conclusion Both amniocentesis and CVS performed in the first trimester of preg‐nancy may impair antenatal lung growth.