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A prospective, randomised, cross‐over study comparing the effects of clomiphene citrate and cyclofenil on endometrial morphology in the luteal phase of normal, fertile women
Author(s) -
LI T. C.,
WARREN M. A.,
MURPHY C.,
SARGEANT S.,
COOKE I. D.
Publication year - 1992
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1992.tb13708.x
Subject(s) - luteal phase , endometrial biopsy , medicine , endometrium , clomifene , gynecology , adverse effect , endocrinology , ovulation , follicular phase , ovulation induction , hormone
Objective To examine the effect of two anti‐oestrogens, clomiphene citrate and cyclofenil, on endometrial morphology in the luteal phase. Design A prospective, randomised, cross‐over study. Setting Jessop Hospital for Women, Sheffield, UK. Subjects 10 women who were previously fertile and regularly cycling. Intervention The administration of clomiphene citrate or cyclofenil in the treatment cycles. A LH timed endometrial biopsy was taken on day LH + 6. Main outcome measures Histological dating and morphometric analysis of the endometrial sample. Results Only one out of 10 subjects had abnormal endometrium. There was no difference in the results between cycles treated with clomiphene citrate and cyclofenil. Conclusions Clomiphene citrate or cyclofenil does not have a major adverse effect on endometrial morphology in the luteal phase of normal fertile subjects. The possible adverse effects of anti‐oestrogens on endometrium may have been previously overestimated.