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Induction of abortion with mifepristone and misoprostol in early pregnancy
Author(s) -
THONG K. JOO,
BAIRD DAVID T.
Publication year - 1992
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1992.tb13707.x
Subject(s) - misoprostol , mifepristone , medical abortion , medicine , obstetrics , abortion , incomplete abortion , pregnancy , prostaglandin analogue , products of conception , vacuum aspiration , gynecology , pessary , regimen , family planning , population , prostaglandin , surgery , research methodology , genetics , biology , environmental health
Objective To investigate the clinical efficacy of the combination of mifepristone and an orally active prostaglandin, misoprostol, for early medical termination. Design Women with amenorrhoea ≤56 days were given 200 mg mifepristone. 48 h later, 600 μg misoprostol was given orally. Setting Medical Termination Unit, Simpson Memorial Maternity Pavilion, Edinburgh. Subjects 100 women requesting medical termination of pregnancy. Interventions Evacuation of uterus for incomplete abortion or on‐going pregnancies. Results One woman had an incomplete abortion prior to administration of misoprostol. 92 (93%) out of 99 women had complete abortion following administration of misoprostol. There were three on‐going pregnancies (3.0%, 95% confidence limits (CL) 0.6‐8.6) and four incomplete abortions with this regimen (4.0%, 95% CL 1.1‐10.0). 24% women vomited and 7% had diarrrhoea following administration of misoprostol. 62% did not require any analgesia. Conclusions The combination of misoprostol with mifepristone is inexpensive, simple, effective, noninvasive and an acceptable alternative to current regimens for medical termination.