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Cancer of the cervix in women under 40 years of age, a regional survey, 1975–1984
Author(s) -
PEEL K. R.,
KHOURY G. G.,
JOSLIN C. A. F.,
O'DONOVAN P. J.,
MGAYA H.,
KEATES G.,
HEAD C.,
THOROGOOD D. J.
Publication year - 1991
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1991.tb15337.x
Subject(s) - medicine , cervix , stage (stratigraphy) , incidence (geometry) , radiation therapy , gynecology , cancer , retrospective cohort study , disease , obstetrics , paleontology , physics , optics , biology
Objective— To review the method and results of treatment of carcinoma of the cervix in women <40 years old. Design— Retrospective review of all available case records. Setting— Yorkshire Regional Health Authority. Subjects— 428 women <40 years old treated for stage IB‐IV carcinoma of the cervix between 1975 and 1984 inclusive. Main outcome measures— Overall survival, by stage, effect of age, identifiable factors of prognostic significance, survival, grade 3 morbidity and pattern of recurrence in relation to treatment. Results— The 5‐year actuarial percentage survival by stage was 78–4 (IB), 54–4 (II), 18–4 (III) and 0 (IV). Identifiable factors of prognostic importance were stage, nodal metastases ( P <0.001 ) and tumour grade ( P <0.01 ). Conclusion— Primary surgical treatment for young women with early disease allows ovarian conservation and the avoidance of radiotherapy in 80% of them. Such treatment results in less local recurrence, particularly evident in patients with moderate or poorly differentiated tumours and a lower incidence of serious morbidity.