Premium
Follicular development in spontaneous and stimulated cycles in women with minimal‐mild endometriosis
Author(s) -
MAHMOOD TAHIR A.,
MESSINIS IOANNIS E.,
TEMPLETON ALLAN
Publication year - 1991
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1991.tb13483.x
Subject(s) - endometriosis , infertility , follicular phase , medicine , ovulation , regimen , unexplained infertility , gynecology , female infertility , clomifene , follicle , obstetrics , andrology , ovulation induction , pregnancy , biology , hormone , genetics
Objective— To study follicle development in women with minimal‐mild endometriosis. Design— In women with endometriosis a spontaneous ovulatory cycle was compared with two subsequent cycles in which either clomiphene or clomiphene and FSH were given to stimulate folliculogenisis. Spontaneous cycles in women with tubal infertility provided a comparison group. Setting— Infertility clinic, Aberdeen Maternity Hospital. Subjects— 17 women with minimal‐mild endometriosis and 10 women with tubal infertility. Interventions— The women with endometriosis were treated with 150 mg clomiphene citrate from days 2 to 6 in one cycle and in a subsequent cycle with 150 mg clomiphene citrate on days 2 to 6 plus 75 iu FSH daily thereafter. Main outcome measures— Follicular size measured daily using ultrasound. Serum FSH estimated on days 5 and 7 and then daily. Results— Spontaneous follicular growth in the women with endometriosis was similar to that in the women with tubal infertility. Follicular development began earlier in cycles with clomiphene/FSH and the leading follicle reached 16 mm 2 days sooner but the rate of growth was similar whether or not either regimen of stimulation was used. Conclusion— Follicular growth is not impaired by minimal‐mild endometriosis. Infertility with this condition cannot be explained by altered follicular growth or responsiveness.