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Quantitative production of prostaglandin E 2 and its metabolites by human fetal membranes
Author(s) -
KHAN H.,
SULLIVAN M. H. F.,
HELMIG R.,
ROSEBLADE C. K.,
ULDBJERG N.,
ELDER M. G.
Publication year - 1991
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1991.tb13461.x
Subject(s) - membrane , fetus , chemistry , prostaglandin , production (economics) , prostaglandin e , biochemistry , biology , pregnancy , genetics , macroeconomics , economics
Summary. Cultured amnion, choriodecidua and intact fetal membrane produced similar quantities of prostaglandin E 2 (PGE 2 ) (1–5 ng/ml). Choriodecidua and intact fetal membrane also produced very high levels of PGE 2 metabolites (100–1000 ng/ml). The total production of PGE (PGE 2 metabolites) was similar in intact fetal membrane and in choriodecidua, suggesting that the amnion, although a source of PGE 2 contributes little to the overall PGE production by fetal membranes.