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A comparative study of ethamsylate and mefenamic acid in dysfunctional uterine bleeding
Author(s) -
CHAMBERLAIN G.,
FREEMAN R.,
PRICE F.,
KENNEDY A.,
GREEN D.,
EVE L.
Publication year - 1991
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1991.tb13460.x
Subject(s) - mefenamic acid , dysfunctional uterine bleeding , blood loss , medicine , double blind , pharmacology , anesthesia , surgery , placebo , alternative medicine , pathology , endometrium
Summary. The effects of ethamsylate and mefenamic acid on menstrual blood loss were compared in a double‐blind trial in 34 women with men‐orrhagia. Both drugs produced statistically significant reductions in blood loss during the 3 months of treatment; the overall reduction was 20% in the ethamsylate group and 24% in the mefenamic acid group. Compared with pretreatment values, blood loss was significantly less in each of the 3 treatment months in the mefenamic acid group, but only in the second and third months of treatment in the ethamsylate group. However, more women had a clinically useful reduction in blood loss (>40%) in the ethamsylate group. The onset of effect of mefenamic acid was rapid but ethamsylate showed a comparatively greater effect as the trial progressed. Cessation of treatment was followed by an increase in blood loss, more pronounced in mefenamic acid group who reverted to pre‐treatment levels. A greater number of side‐effects were reported with mefenamic acid.