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Is GIFT (gamete intrafallopian transfer) the best treatment for unexplained infertility?
Author(s) -
MURDOCH A. P.,
HARRIS M.,
MAHROO M.,
WILLIAMS M.,
DUNLOP W.
Publication year - 1991
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1991.tb13449.x
Subject(s) - gamete intrafallopian transfer , infertility , pregnancy , unexplained infertility , obstetrics , live birth , medicine , fertility , pregnancy rate , gynecology , assisted reproductive technology , population , biology , genetics , environmental health
Objective— To compare the cumulative pregnancy rates after gamete intrafallopian transfer (GIFT) with the cumulative spontaneous pregnancy rates in couples with unexplained infertility. Design— A contemporaneous study in a single group of patients. Setting— Northern Regional Fertility Centre. Subjects— 76 couples with unexplained infertility of more than 3 years duration Interventions— Successful pregnancies were recorded during at least 3 months before GIFT and up to 21 months after a maximum of three cycles of GIFT treatment. Main outcome measures— Pregnancy resulting in a live birth. Results— Average monthly fecundability without treatment was 0.021 and after GIFT was 0.14 ( P <0.001 ). This was reflected as a cumulative pregnancy rate of 52% after three cycles of GIFT and 30% after 24 months without treatment Conclusions— The chance of having a baby after one cycle of GIFT is significantly greater than the chance in a spontaneous cycle. However, considering the cumulative pregnancy rates, we suggest that if GIFT is to be a realistic treatment option, it should be offered for more than one cycle.