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Platelet angiotensin II binding sites in normotensive and hypertensive women
Author(s) -
BAKER PHILIP N.,
PIPKIN FIONA BROUGHTON,
SYMONDS E. MALCOLM
Publication year - 1991
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1991.tb10336.x
Subject(s) - medicine , platelet , pregnancy , endocrinology , angiotensin ii , third trimester , eclampsia , fetus , receptor , biology , genetics
Summary. Specific binding of angiotensin II (AII) to platelets was measured in 89 women, 25 nulliparous non‐pregnant women and 64 primigravida in the third trimester of pregnancy. There was significantly lower binding in the 25 pregnant women who were normotensive (2.3 fmol/10 9 cells) when compared with the non‐pregnant women (9.0 fmol/10 9 cells P <0.001 ). Significantly higher platelet AII binding levels were found in the 39 women who had pregnancy induced hypertension (PIH) (5.5 fmol/10 9 cells) when compared with the 25 normotensive pregnant women ( P <0.001 ). Of the 39 women with PIH, platelet AII binding was higher in the 23 women who had pre‐eclampsia (7.0 fmol/10 9 cells), when compared with the 16 who had non‐proteinuric PIH, (4.6 fmol/10 9 cells) although the difference was not statistically significant ( P <0.04 ). The pressor response to AII is also diminished in pregnancy, yet less so if pregnancy induced hypertension develops. Platelets may provide a readily accessible tissue with which to study AII responsiveness in pregnancy.