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Oestrogen and progesterone receptor content as a prognostic factor in advanced epithelial ovarian carcinoma
Author(s) -
SEVELDA PAUL,
DENISON URSULA,
SCHEMPER MICHAEL,
SPONA JÜRGEN,
VAVRA NORBERT,
SALZER HEINRICH
Publication year - 1990
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1990.tb16243.x
Subject(s) - progesterone receptor , ascites , medicine , ovarian cancer , epithelial ovarian carcinoma , proportional hazards model , stage (stratigraphy) , oncology , ovarian carcinoma , ovary , carcinoma , endocrinology , biology , cancer , estrogen receptor , breast cancer , paleontology
Summary. Levels of oestrogen receptor (ER) and progesterone receptor (PgR) in ovarian cancer tissue were examined with regard to their prognostic importance for survival in 179 patients with primary epithelial ovarian cancer stage III or IV in relation to: FIGO‐stage, histological type, histological grade, age, ascites, and postoperative residual tumour. Hormone receptor content was determined with the DCC‐method, receptor values higher than 9 fmol/mg protein were considered positive. Response to postoperative chemotherapy was significantly correlated with PgR content (80% responders in the group with PgR positive tumours and only 61% responders in the group with PgR negative tumours). A Cox proportional hazards regression model identified histological grade, residual tumour, age and PgR content as independent prognostic factors for survival in advanced epithelial ovarian carcinoma. PgR content had particularly significant prognostic relevance for patients with postoperative residual tumour mass ≤2 cm in diameter. Within this group of patients, those who are PgR positive have a 2‐years survival probability of 83% compared with only 51% in the Pg R‐negative group.