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Determinants of fetal and maternal atrial natriuretic peptide concentrations at delivery in man
Author(s) -
VOTO LILIAN A S.,
HETMANSKI DAVID J.,
PIPKIN FIONA BROUGHTON
Publication year - 1990
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1990.tb02500.x
Subject(s) - atrial natriuretic peptide , umbilical artery , medicine , fetus , umbilical vein , caesarean section , vaginal delivery , endocrinology , pregnancy , peptide hormone , venous blood , obstetrics , cardiology , hormone , chemistry , biology , biochemistry , in vitro , genetics
Summary. Matched maternal venous (MV), umbilical artery (UA) and umbilical vein (UV) concentrations of atrial natriuretic peptide [ANP] were measured in 36 normotensive women at term delivery (23 vaginal, 13 caesarean) and 17 non‐pregnant women in the first half of the menstrual cycle. MV [ANP] at caesarean section was similar to that in nonpregnant women, but UA and UV [ANP] were higher ( P <0.01 for both). UA, but not UV, [ANP] was markedly raised after vaginal delivery. Plasma concentrations of aldosteronce[ALD] were measured in 16 of the matched sets of samples. No statistically significant association was found between [ANP] and [ALD] in either maternal or fetal samples. Neither maternal nor fetal [ANP] correlated with serum Na + or osmolality, haematoerit, blood pressure or heart rate.