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A longitudinal study of platelet behaviour and thromboxane production in whole blood in normal pregnancy and the puerperium
Author(s) -
LOUDEN K. A.,
PIPKIN F. BROUGHTON,
HEPTINSTALL S.,
FOX S. C.,
MITCHELL J. R. A.,
SYMONDS E. M.
Publication year - 1990
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1990.tb02498.x
Subject(s) - pregnancy , platelet , thromboxane , medicine , arachidonic acid , thromboxane b2 , endocrinology , third trimester , early pregnancy factor , whole blood , thromboxane a2 , obstetrics , gestation , chemistry , biology , biochemistry , enzyme , genetics
Summary. A longitudinal study of platelet behaviour (platelet aggregation and release reaction) in whole blood and of serum thromboxane B 2 production was performed before, during and after normal pregnancy. The response of platelets to arachidonic acid and to adrenaline was significantly increased in the third trimester. Six weeks after delivery, values were still modestly increased but return to non‐pregnant values was complete by 12 weeks. Serum thromboxane B 2 production was unchanged throughout pregnancy and the puerperium.