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Gonadotrophin releasing hormone agonist (buserelin) in the treatment of endometriosis: changes in the extent of the disease and in CA 125 serum levels after 6‐month therapy
Author(s) -
MARANA R.,
MUZH L.,
MUSCATELLO P.,
LANZONE A.,
CARUSO A.,
DELL'ACQUA S.,
MANCUSO S.
Publication year - 1990
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1990.tb02474.x
Subject(s) - buserelin , endometriosis , agonist , medicine , endocrinology , hormone , luteinizing hormone , laparoscopy , receptor , surgery
Summary. Twenty‐two women with endometriosis were treated with the luteinizing hormone‐releasing hormone (LHRH) agonist buserelin for 6 months. At second‐look laparoscopy the mean score of endometriosis had decreased from 23.1 (SD 17.0) to 17.2 (SD 20.2) ( P <0.05). CA 125 serum levels decreased from 38.4 (SD 32.2) U/ml at diagnosis to 15.5 (SD 7.0) at second look (P<0.005). CA 125 levels correlated at diagnosis with total score of endometriosis (P<0.05) and with active score of endometriosts (P<0.05), but not with the adhesion score. CA 125 levels were not correlated with endometriosis scores at second look laparoscopy, thus suggesting that mechanisms other than the change in the extent of the disease may be involved in the CA 125 decrease during therapy. CA 125 levels may therefore not be a reliable indicator for monitoring the efficacy of LHRH agonist treatment of endometriosis.