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Preventing IUCD‐related pelvic infection: the efficacy of prophylactic doxycycline at insertion
Author(s) -
SINEI S. K. A.,
SCHULZ K. F.,
LAMPTEY P. R.,
GRIMES D. A.,
MATI J. K. G.,
ROSENTHAL S. M.,
ROSENBERG M. J.,
RIARA G.,
NJAGE P. N.,
BHULLAR V. B.,
OGEMBO H. V.
Publication year - 1990
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1990.tb01828.x
Subject(s) - pelvic inflammatory disease , medicine , doxycycline , randomized controlled trial , placebo , intrauterine device , incidence (geometry) , clinical trial , surgery , gynecology , family planning , population , antibiotics , physics , alternative medicine , environmental health , optics , pathology , microbiology and biotechnology , research methodology , biology
Summary. Most of the small increased risk in pelvic inflammatory disease (PID) associated with the intrauterine contraceptive device (IUCD) appears to be caused by bacterial contamination of the endometrial cavity at the time of insertion. This randomized clinical trial of 1813 women in Nairobi, Kenya, assessed the effectiveness of 200 mg of doxycycline given orally at the time of insertion in reducing the occurrence of PID. The rate of this infection in the doxycycline‐treated group was 31% lower than that in the placebo‐treated group (1.3 and 1.9%, respectively; RR 0.69; 95% CI 0.32 to 1–5). The rate of an unplanned IUCD‐related visit to the clinic was also 31% lower in the doxycycline‐treated group (RR 0.69; 95% CI 0.52 to 0.91). Although the significance level ( P = 0.17) for the reduction is PID does not meet the conventional standard of 0.05, the results may be suggestive of an effect. Moreover, the reduction in IUCD‐related visits ( P = 0.004) not only represents an important decrease in morbidity but also substantiates the reduction found for PID. Further studies are needed to corroborate these results. Consideration should be given to the prophylactic use of doxycycline at the time of IUCD insertion as an approach to preventing PID and other lUCD‐related morbidity.