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Fetal growth achievement and neurodevelopmental disability
Author(s) -
TAYLOR D. J.,
HOWIE P. W.
Publication year - 1989
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1989.tb03317.x
Subject(s) - fetus , medicine , confounding , fetal growth , gestation , obstetrics , population , pediatrics , pregnancy , biology , genetics , environmental health
Summary. To investigate the role played by chronic intrauterine insult in the genesis of neurodevelopmental disability (NDD), three analyses have been applied to a case‐controlled study which compared a population of children with NDD with a control group of normally developed children. In the first analysis, average birthweight in children with NDD was 3138 g (SD 592) which was significantly less than in normally developed children, 3280 g (SD 491) ( P <0·0005). After correction for confounding factors, birthweight‐for‐gestation (Z score) remained lower in children with NDD (‐0·42) than normal children (‐0·21) ( P <0·0025). In the second analysis the fetal growth achievement of children, who had NDD after the prenatal complications, severe hypertension, unclassified antepartum haemorrhage and preterm uterine activity, was significantly less ( Z score, ‐0·76) than children who were normally developed after the same maternal prenatal complications ( Z score, ‐0·37) ( P <0·03). In the third analysis, a risk analysis to assess the relative importance of fetal growth achievement and prenatal complications in the genesis of NDD suggested that the latter was the dominant factor. These data are consistent with the hypothesis that prenatal complications, severe enough to retard fetal growth, can compromise fetal brain development and make an important contribution to NDD.