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Placental hormones and maternal glucose metabolism. A study of fetal growth in normal pregnancy
Author(s) -
LANGHOFFROOS JENS,
LINDMARK GUNTLLA,
WIBELL LARS,
GEBREMEDHIN MEHARI
Publication year - 1989
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1989.tb02392.x
Subject(s) - pregnancy , hormone , fetus , metabolism , fetal growth , endocrinology , placenta , medicine , physiology , biology , genetics
Summary The interrelations between three placental hormones (oestradiol, progesterone and hPL), maternal glucose metabolism, maternal anthropometry and fetal growth were studied in a sample of 52 carefully selected pregnant women. A relation was found between infant birthweight and both fasting blood glucose and t ½ of glucose of an intravenous glucose tolerance test at week 37 of pregnancy. The serum concentrations of the placental hormones were not significantly related to the glucose variables. The correlation between birthweight and the maternal levels of hPL in late pregnancy ( r = 0·60) persisted when fasting blood glucose and tt ½ of glucose were taken into account. Maternal fat mass was found to explain more of the Variation in basal insulin levels around week 37 than did the placental hormones.