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Tocolysis during cervical ripening with vaginal PGE 2
Author(s) -
INSULL G. M.,
COOKE INEZ,
MacKENZIE I. Z.
Publication year - 1989
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1989.tb01658.x
Subject(s) - medicine , cervix , adverse effect , salbutamol , placental abruption , vaginal delivery , obstetrics , cervical dilatation , labor induction , pregnancy , induction of labor , bishop score , anesthesia , gynecology , oxytocin , gestation , cancer , biology , asthma , genetics
Summary. Forty‐two primigravidae with unripe cervices (modified Bishop score ≤5) were pretreated with 8 mg of oral salbutamol 30 min before vaginal administration of 5 mg of PGE 2 . The proportion of patients in established labour after treatment (19%) was markedly less than results reported previously and cervical improvement occurred in 86% of the non‐labouring patients. The improved outcome of labour associated with the prior administration of PGE 2 when the cervix is unripe, including reduced induction‐to‐delivery intervals and higher rates of vaginal delivery was maintained. Apart from some minor side‐effects, there were no adverse effects noted as a direct consequence of the tocolytic; blood loss was not increased, although one patient suffered an intrapartum abruption. This approach allows a greater control of induced uterine activity and timing of delivery which may be of particular importance in women with suspected placental insufficiency.

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