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A randomized trial of the use of cocaine spray to provide pain relief during laser vaporization of the cervix
Author(s) -
MIKHAIL M. G. S.,
BEVAN J. R.
Publication year - 1988
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1988.tb12798.x
Subject(s) - cervix , visual analogue scale , placebo , medicine , randomized controlled trial , cervical intraepithelial neoplasia , anesthesia , placebo group , surgery , cervical cancer , cancer , pathology , alternative medicine
Summary. In a double‐blind trial, 50 patients undergoing laser vaporization of the cervix for cervical intraepithelial neoplasia were randomly allocated to one of two groups. One group had the cervix sprayed with 3–4 ml of a solution containing 10% cocaine, the other a placebo solution during the laser treatment. Women in the cocaine group had significantly less pain as assessed by a visual analogue scale ( P < 0.001) and by a verbal rating scale ( P = 0.002). The cocaine group also had less blood loss ( P = 0.001) as assessed subjectively by the operator.