Premium
The serum pregnancy‐specific β 1 ‐glycoprotein to betahuman chorionic gonadotrophin ratio as an index of prognosis in patients with choriocarcinoma
Author(s) -
SAKURAGI NORIAKI,
OHKUBO HITOSHI,
YAMAMOTO RITSU,
SHIINA YOSHIHIRO,
TANAKA TOSHINOBU,
ICHINOE KIHYOE,
FUJIMOTO SEIICHIRO
Publication year - 1988
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1988.tb09494.x
Subject(s) - choriocarcinoma , chemotherapy , medicine , pregnancy , gastroenterology , gynecology , oncology , biology , genetics
Summary. The ratio of serum pregnancy‐specific β 1 ‐glycoprotein (SP1) to the β‐subunit of human chorionic gonadotrophin (β‐hCG) before and after chemotherapy was measured in 12 patients with metastatic choriocarcinoma. The ratios before chemotherapy ranged between 0 . 03 and 0 . 75, with a mean value of 0 . 34 (SD 0 . 21). The ratio increased to over 1 . 0 (1 . 05–53 . 3) after one or two courses of chemotherapy in seven of the 12 patients. These women achieved complete remission. In the other five patients who died of the disease due to drug resistance of the tumour, the ratio after chemotherapy was low (0 . 04–0 . 74) and tended to decline. These data suggest that the serum SPl/β‐hCG ratio can be used to predict the prognosis of patients with choriocarcinoma.