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The effect of the antiprogestin mifepristone (RU 486) on maturation and in‐vitro fertilization of human oocytes
Author(s) -
MESSINIS IOANNIS E.,
TEMPLETON ALLAN
Publication year - 1988
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1988.tb09489.x
Subject(s) - follicular fluid , mifepristone , oocyte , human fertilization , in vitro fertilisation , andrology , human chorionic gonadotropin , follicle , follicular phase , chemistry , medicine , endocrinology , biology , hormone , pregnancy , embryo , anatomy , microbiology and biotechnology , genetics
Summary. The effect of RU 486 (mifepristone), a potent antiprogestin, on the in‐vitro fertilization of human oocytes was investigated. In 40 normal volunteer women requesting laparoscopic sterilization, follicle aspiration for oocyte recovery was attempted 34 h after the injection of 5000 i.u. human chorionic gonadotrophin (hCG). Twenty women were allocated to receive 100 mg RU 486 orally 1 h before the hCG injection, the remaining 20 women acted as controls. There was no significant difference in the cleavage rate of the ooctyes after fertilization in vitro between the two groups (56% and 66% respectively). Also, the morphological characteristics of the cleaving oocytes and the concentrations of oestradiol, progesterone and androstenedione in the follicular fluid of the leading follicle did not differ significantly between the two groups. Since RU 486 was detected in substantial amounts in the follicular fluid specimens, these results suggest that progesterone is not critical for the final stages of human oocyte maturation.