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Increased uterine prostaglandin E receptors in menorrhagic women
Author(s) -
ADELANTADO JUAN MARIA,
REES MARGARET C. P.,
BERNAL ANDRÉS LÓPEZ,
TURNBULL ALEXANDER C.
Publication year - 1988
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1988.tb06846.x
Subject(s) - hysterectomy , medicine , receptor , blood loss , uterus , gynecology , prostaglandin e , obstetrics , endocrinology , surgery
Summary. PGE receptor concentrations were measured in myometrial samples collected from 10 women at hysterectomy. Five women had normal measured menstrual blood loss (35–44 ml) and the remainder had unexplained menorrhagia occurring in the absence of any uterine, pelvic or general pathology, with losses ranging from 85 to 925 ml. Median PGE receptor concentrations were significantly higher in the women with menorrhagia (1077 fmol/mg protein) than in the women with normal menstrual blood loss (625 fmol/mg protein) and correlated with menstrual blood loss ( P <0·02). These findings suggest that unexplained menorrhagia may simply be a constitutional variant in some women and that specific and potent PGE uterine receptor antagonists would furnish effective non‐surgical treatment for unexplained menorrhagia.