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Factors associated with progression of cervical human papillomavirus (HPV) infections into carcinoma in situ during a long‐term prospective follow‐up
Author(s) -
SYRJÄNEN K.,
MÄNTYJÄRVI R.,
SAARIKOSKI S.,
VÄYRYNEN M.,
SYRJÄNEN S.,
PARKKINEN S.,
YLISKOSKI M.,
SAASTAMOINEN J.,
CASTREN O.
Publication year - 1988
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1988.tb06785.x
Subject(s) - concomitant , carcinoma in situ , medicine , biopsy , cervix , human papillomavirus , prospective cohort study , hpv infection , cervical cancer , gynecology , carcinoma , oncology , cancer
Summary. In the course of a prospective study of 508 women with papillomavirus (HPV) lesions of the uterine cervix, 66 lesions that progressed into carcinoma in situ (CIS) were identified and treated by conization during a mean follow‐up period of 35 months. The lesions were investigated with light microscopy and with in‐situ DNA hybridization using 35 S‐labelled probes for HPV 6,11,16,18, 31 and 33. After radical cone treatment, 11 of the 66 women (16‐7%) have presented with a recurrent HPV infection. The recurrence rate increased with the duration of the follow‐up period from <10% at the mean follow‐up of 25 months to 16.7% at the most recent follow‐up at 35 months. Most of these 66 HPV lesions (89%) presented with concomitant CIN in the first punch biopsy, but it is noteworthy that the other 11 % presented without concomitant CIN. HPV DNA of at least one of the six types examined was found in 73% of the first biopsies and it is noteworthy that the so‐called ‘low‐risk’ types, HPV 6 and 11, were found as frequently as the ‘high‐risk’ types, HPV 16 and 18 (18% and 17%, respectively). This would suggest a similarity in the biological behaviour of these two HPV groups. Although the concept of the ‘high‐risk’ and ‘low‐risk’ HPV types may remain at least partially valid, it is imperative to realize that infection by HPV 6 and 11 by no means excludes the possibility for clinical progession into CIS and eventually to an invasive carcinoma.