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The treatment of normospermic infertility by gamete intrafallopian transfer (GIFT)
Author(s) -
YOVICH JOHN L.,
MATSON PHILLIP L.,
BLACKLEDGE DAVID G.,
TURNER SIMON R.,
RICHARDSON PETER A.,
YOVICH JEANNE M.,
EDIRISINGHE W. ROHINI
Publication year - 1988
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1988.tb06606.x
Subject(s) - gamete intrafallopian transfer , gynecology , infertility , pregnancy , pregnancy rate , obstetrics , medicine , endometriosis , biology , genetics
Summary. Gamete intrafallopian transfer (GIFT) was applied in 207 treatment cycles in 73 couples. The pregnancy rate in cycles with only one (2/21, 9·5%) or two (2/29, 6·9%) oocytes transferred was significantly less than that in which four oocytes (36/116, 31·0%) were replaced. The collection of more than four oocytes did not influence the pregnancy rate in that treatment cycle. The overall pregnancy rate was 24·2% (50 of 207) and was similar in the four infertility groups studied (non‐occlusive tubal disorders, endometriosis, cervical factor and unexplained infertility) with 28 (56%) of the pregnancies delivered at 20 weeks. The pregnancy wastage included 4 (8%) ectopic pregnancies and 3 (6%) late pregnancy losses. The 12 multiple pregnancies occurred following the transfer of three and four oocytes.