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Immunohistochemical study of cytoplasmic oestradiol receptor in normal, dysplastic and malignant cervical tissue
Author(s) -
HENRY R. J. W.,
GOODMAN J. D. S.,
GODLEY M.,
RAJU K. S.,
COFFER A. I.,
KING R. J. B.
Publication year - 1988
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1988.tb06582.x
Subject(s) - immunoperoxidase , endocervix , pathology , dysplasia , immunohistochemistry , stain , cervix , cytoplasm , staining , monoclonal antibody , biology , medicine , uterine cervix , antibody , carcinoma , cancer , immunology , biochemistry
Summary. Using a monoclonal antibody raised against an oestrogen receptor‐related protein, p29, and an indirect immunoperoxidase technique to stain human tissue, the presence of the antigen was investigated in normal, dysplastic and malignant tissue of the uterine cervix. In normal tissue p29 was present throughout the ectocervix during the menstrual cycle and virtually absent from the endocervix. In dysplastic cervical tissue there was a decreasing p29 content with increasing severity of the dysplasia, and very low levels were seen in the carcinomatous tissues.