Premium
Gestational‐age‐dependent concentrations of polyamines, their conjugates and metabolites in urine and amniotic fluid
Author(s) -
BERG GITA A.,
KINGMA ANNEKE W.,
VISSER GERARD H. A.,
MUSKIET FRITS A. J.
Publication year - 1988
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1988.tb06528.x
Subject(s) - spermine , putrescine , amniotic fluid , spermidine , urine , chemistry , polyamine , pregnancy , biochemistry , endocrinology , fetus , medicine , andrology , biology , enzyme , genetics
Summary. The metabolism and fate of polyamines during cell proliferation, differentiation, and cell loss were investigated by measuring the concentration of polyamines, their conjugates and some of their metabolites in amniotic fluid of 24 subjects, and in urine of 85 women during pregnancy. The increase of putrescine and spermine in acid‐hydrolysed urines during pregnancy appeared to be almost completely due to increases in monoacetylated putrescine and N l ,N 12 diacetylated spermine, respectively. The latter two were the quantitatively most important polyamines in amniotic fluid. In urine, monoacetylated putrescine showed the highest levels at the end of pregnancy, whereas N 1 ,N 12 diacetylated spermine reached the highest values at about 32 weeks gestation. It was impossible to establish whether extracellular monoacetylated putrescine is linked either to cell growth or cell loss. The appearance of N l ,N 12 diacetylated spermine is probably due to cell loss and dependent on the degree of differentiation during fetal development. The decline and eventual disappearance of urinary N l ,N 12 diacetylated spermine during the first 2 years after birth may be coherent with maturation of the FAD‐dependent polyamine oxidase activity.