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Effects of seven low dose combined oral contraceptives on high density lipoprotein subfractions
Author(s) -
VANGE N. VAN DER,
KLOOSTERBOER H. J.,
HASPELS A. A.
Publication year - 1987
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1987.tb03151.x
Subject(s) - desogestrel , levonorgestrel , cyproterone acetate , norethisterone , endocrinology , medicine , chemistry , gestodene , ethinylestradiol , norgestrel , cholesterol , high density lipoprotein , norethisterone acetate , population , estrogen , hormone , research methodology , family planning , androgen , environmental health
Summary The effects on lipid metabolism of seven combined oral contraceptives were investigated, particularly the effects on high density lipoprotein (HDL) subfractions, which were separated by density gradient ultracentrifugation. There were no differences between the preparations in the effects on the LDL fraction, the so‐called atherogenic particle, but there were marked differences in the effects on the anti‐atherogenic HDL fraction, of which the effects on HDL‐2 were most pronounced. After treatment with monophasic cyproterone acetate and biphasic desogestrel, the cholesterol and phospholipid contents of the HDL‐2 fraction were significantly higher than those found after treatment with the other preparations. The lowest values were found after treatment with monophasic levonorgestrel, whereas monophasic desogestrel, triphasic levonorgestrel, monophasic norethisterone and triphasic gestoden induced intermediate values for these variables. The levels of HDL‐2 reflect the intrinsic androgenicity of the various progestogens used in the preparations.