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Fetal and uteroplacental haemodynamics during short‐term atenolol treatment of hypertension in pregnancy
Author(s) -
MONTAN SVEN,
LIEDHOLM HANS,
LINGMAN GÖRAN,
MARŠÁL KAREL,
SJÖBERG NILSOTTO,
SOLUM THORE
Publication year - 1987
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1987.tb03097.x
Subject(s) - atenolol , hemodynamics , pregnancy , medicine , fetus , term (time) , obstetrics , cardiology , blood pressure , biology , genetics , physics , quantum mechanics
Summary Fetal circulation was studied by means of combined realtime and pulsed Doppler ultrasound in 14 women with pregnancy‐associated hypertension before and during the first and third days of treatment with the β 1 ‐selective blocker, atenolol; in seven of the women the maternal uterine arcuate blood velocity waveform was also studied. Blood flow characteristics were normal both in the fetus and in the maternal arcuate artery, compared with those in uncomplicated pregnancies of corresponding gestational ages. Volume blood flow remained unchanged in the fetal descending aorta, and in the umbilical vein during atenolol treatment, whereas the pulsatility index increased in the fetal descending aorta and in the arcuate artery. This suggests that the peripheral vascular resistance, both on the maternal and fetal side of the placenta, increased during short‐term antihypertensive treament with atenolol.