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A comparison of the effects of maternally administered meptazinol and pethidine on neonatal acid‐base status
Author(s) -
BOER FRANCES C.,
CLIFFORD WAYNE A.,
SHORTLAND DAVID,
SIMPSON RONALD L.,
CATLEY DAVID M.
Publication year - 1987
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1987.tb02364.x
Subject(s) - pethidine , anesthesia , respiratory acidosis , pco2 , bicarbonate , medicine , acid–base homeostasis , analgesic , acidosis
Summary. A randomized double‐blind study compared the effects of equi‐analgesic doses of maternally administered meptazinol (1.5 mg/kg) and pethidine (1.5 mg/kg) on neonatal acid‐base status. Heel‐prick samples were taken for assessment of acid‐base status at 10 and 60 min after delivery. Maternal antenatal history, details of labour and neonatal status at delivery were also recorded. Meptazinol produced less neonatal respiratory depression than pethidine: the mean 10 min acid‐base data from 16 infants whose mothers received pethidine were indicative of a respiratory acidosis (pH 7.13, SD 0.08, P co 2 ,9.11, SD 2.2 kPa; standard bicarbonate 22.3, SD 3.1 mmol/1). This was not evident in the mean acid‐base data from 16 infants whose mothers received meptazinol (pH 7.23, SD 0.07; P co 2 6.83, SD 1.6 kPa; standard bicarbonate 20.9, SD 4.2 mmol/1). The mean pH and P co 2 in the two treatment groups were significantly different (P<0.002) at 10 min but not at 60 min after delivery.