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The effects of ethanol methotrexate and diphenylhydantoin on [ 14 C] leucine incorporation by human trophoblast cells cultured in vitro
Author(s) -
LANDON M. J.,
TOOTHILL VALERIE J.,
MORGAN D. M. L.
Publication year - 1987
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1987.tb02363.x
Subject(s) - methotrexate , trophoblast , in vitro , ethanol , leucine , chemistry , drug , cell culture , pharmacology , biochemistry , biology , medicine , fetus , amino acid , pregnancy , placenta , genetics
Summary. The effects of alcohol, diphenylhydantoin and methotrexate on protein synthesis by human trophoblast have been studied in vitro using a cell culture technique. None of the drugs depressed protein synthesis at pharmacological levels and for diphenylhydantoin there was evidence that the cellular accumulation of this drug was negligible.