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Prophylactic blood transfusion in maternal sickle cell syndromes
Author(s) -
TUCK SUSAN M.,
BREWSTER E. M.,
STUDD J. W. W.,
JAMES CATHERINE E.,
PEARSON T. C.
Publication year - 1987
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1987.tb02337.x
Subject(s) - medicine , pregnancy , blood transfusion , prospective cohort study , disease , obstetrics , prophylactic treatment , red blood cell , retrospective cohort study , antibody , pediatrics , fetus , intensive care medicine , immunology , surgery , genetics , biology
Summary. An assessment of the benefits of prophylactic blood transfusion during 51 pregnancies in women with haemoglobin SS, haemoglobin SC and haemoglobin S‐β‐thalassaemia in a retrospective study from 1978 to 1984 has failed to demonstrate any clear conclusions as to their efficacy. Of the transfused patients, 22% developed atypical red cell antibodies and 14% had immediate minor transfusion reactions. Our data show no significant difference in fetal or maternal outcome between those patients who were transfused prophylactically and those who were not. A prospective study to clarify the appropriate place of this important aspect of management in women with sickle cell disease in pregnancy is suggested.