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Fertility and obstetric history in patients with familial Mediterranean fever on long‐term colchicine therapy
Author(s) -
EHRENFELD MICHAEL,
LEVY MICHA,
ELIAKIM MARCEL,
BRZEZINSKI AM
Publication year - 1987
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1987.tb02320.x
Subject(s) - familial mediterranean fever , colchicine , fertility , medicine , term (time) , pregnancy , pediatrics , intensive care medicine , obstetrics , environmental health , biology , disease , population , genetics , physics , quantum mechanics
Summary. The obstetric histories were examined for 36 women with familial Mediterranean fever (FMF) on long‐term colchicine treatment followed for periods ranging between 3 and 12 years. Seven of 28 pregnancies (25%) associated with colchicine therapy ended in miscarriage. Thirteen women (36%) had periods of infertility; these were due to ovulatory dysfunction in six women, to peritoneal adhesions in four and remained unexplained in three women. The rates for miscarriage and infertility are high but are similar to those reported for women with FMF before colchicine therapy was introduced. All 16 infants born to mothers who had taken colchicine during pregnancy were healthy. Currently, we do not advise discontinuation of colchicine before planned pregnancy but recommend amniocentesis for karyotyping and reassurance.