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Production of prostacyclin, 6‐keto‐PGF lα and thromboxane B 2 by human umbilical vessels increases from the placenta towards the fetus
Author(s) -
BENEDETTO C,
BARBERO M,
REY L,
ZONCA M,
MAAOBRIO M,
ROCCA G.,
SLATER T.F.
Publication year - 1987
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1987.tb02317.x
Subject(s) - prostacyclin , placenta , thromboxane , fetus , umbilical vein , thromboxane a2 , obstetrics , endocrinology , andrology , medicine , chemistry , pregnancy , biology , biochemistry , platelet , in vitro , genetics
Summary. The aim of this study was to investigate the production of prostacyclin (PGI 2 ) and thromboxane B 2 (TXB 2 ) by incubated samples of umbilical arteries and veins taken at different distances (2, 10,20,30 cm) from the placenta to provide additional information relevant to the haemodynamics of umbilical blood flow. The production of PGI 2 , and 6‐keto‐PGF 1α (the stable metabolite of PGI 2 ), was higher in both veins and arteries as the distance from the placenta at which the vessels were sampled was increased. A similar correlation between production by venous rings and distance from the placenta was observed for TXB 2 , but there was no apparent gradient of TXB 2 production by the samples of arterial rings. No statistically significant variations were discernible in the ratio of 6‐keto‐PGF 1α :TXB 2 (∼50 in the veins and ∼20 in the arteries) in relation to the sampling distance. The significance of these high ratios is discussed in relation to umbilical blood flow and fetal well‐being and development.