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Alpha interferon in human pregnancy
Author(s) -
CHARD T.,
CRAIG P. H.,
MENABAWEY M.,
LEE C.
Publication year - 1986
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1986.tb08635.x
Subject(s) - fetus , decidua , amniotic fluid , immunoradiometric assay , placenta , interferon , pregnancy , alpha (finance) , andrology , alpha interferon , endocrinology , biology , immunology , medicine , obstetrics , radioimmunoassay , surgery , construct validity , genetics , patient satisfaction
Summary. The concentration of interferon‐alpha was measured by a specific two‐site immunoradiometric assay in a variety of fluids and tissues collected during human pregnacy. Maternal blood and blood and tissues from non‐pregnant adults contained little or no interferonalpha. Fetal blood, fetal organs, placenta, membrances, amniotic fluid and decidua all contained significant and roughly equivalent amounts ranging from 1:1 to 10 u/ml (or per g of tissue). These findings demonstrate that the fetus and its immediate surroundings are permeated with interferon. It is suggested that this may play a role in regulation of the maternal‐fetal graft relation.