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Intracellular binding proteins for retinol and retinoic acid in early and term human placentas
Author(s) -
GREEN TIMOTHY,
FORD HENRY C.
Publication year - 1986
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1986.tb07991.x
Subject(s) - retinoic acid , retinol , cytosol , retinol binding protein , sephadex , placenta , intracellular , biochemistry , retinoic acid receptor , vitamin , biology , chemistry , fetus , pregnancy , enzyme , genetics , gene
Summary. Specific binding of both [ 3 H]retinol and [ 3 H]retinoic acid was observed in the cytosol fraction from term placentas and specific binding of [ 3 H]retinol but not [ 3 H] retinoic acid was detected in the cytosol fraction from placentas of 8–12 week pregnancies. The elution volume of the bound radioactivity on Sephadex G‐100 column chromatography was within the range expected for proteins of molecular weight 14500, in agreement with the results of others for cellular retinol‐and retinoic acid‐binding proteins from other tissues. The role of these proteins in mediating the effects of vitamin A on growth and differentiation of the placenta and fetus has yet to be determined.