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Parental age and risk of complete and partial hydatidiform mole
Author(s) -
PARAZZINI F.,
VECCHIA C. LA,
PAMPALLONA S.
Publication year - 1986
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1986.tb07957.x
Subject(s) - mole , partial hydatidiform mole , relative risk , medicine , pregnancy , confidence interval , biology , fetus , genetics , placenta
Summary. The relation between age of parents and the risk of complete and partial hydatidiform mole was examined using data from a casecontrol study conducted in Northern Italy of 149 histologically confirmed complete moles, 45 partial moles and 306 controls subjects who delivered normal babies. Compared to women aged 21 to 35, the relative risk (RR) of complete mole was elevated for teenage women (RR = 1·9) and for those aged 36–40 (RR = 1·9) or over 40 (RR = 7·5). There was no association between women's age and partial mole. Likewise, older paternal age (>45) was related with the risk of complete mole (RR = 4·9, though allowance for women's age reduced this point estimate to 2·9), but not of partial mole. The present findings indicate that there are important differences in the epidemiology of complete and partial hydatidiform mole.