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Enhanced platelet release reaction related to arterial plasma adrenaline and blood pressure in pre‐eclampsia
Author(s) -
ØIAN PÅL,
LANDE KNUT,
KJELDSEN SVERRE ERIK,
GJESDAL KNUT,
AAKESSON INGVAR,
EIDE IVAR,
MALTAU JAN MARTIN
Publication year - 1986
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1986.tb07952.x
Subject(s) - eclampsia , blood pressure , platelet , medicine , epinephrine , anesthesia , cardiology , pregnancy , biology , genetics
Summary. The platelet release product β‐thromboglobulin (BTG) in venous plasma, and arterial and venous catecholamines were measured in 13 severe pre‐eclamptic and 13 normotensive pregnant women. In the pre‐eclamptic group, BTG was significantly higher and the platelet count significantly lower than in the normotensive pregnant group. In the pre‐eclamptic group, arterial concentrations were significantly higher for adrenaline, noradrenaline and dopamine, whereas in venous plasma only adrenaline and dopamine were higher. Significant positive correlations appeared in the pre‐eclamptic patients between venous BTG and arterial adrenaline ( r = 0·82), arterial noradrenaline (r = 0·76) and venous adrenaline ( r = 0·55). In the pre‐eclamptic group, BTG also highly correlated with systolic (r = 0·84) and diastolic blood pressure ( r = 0·77) and heart rate ( r = 0·67). These findings indicate that sympathetic nervous tone, as measured by arterial and venous plasma catecholamines, is a good predictor of in‐vivo blood platelet activation. In pre‐eclampsia, increased sympathetic tone may play a key role in platelet activation and consumption and thus in the activation of the coagulation system.