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Haemodynamic changes and left ventricular performance during high‐dose oestrogen administration to male transsexuals
Author(s) -
SLATER ANTHONY J.,
GUDE NEIL,
CLARKE IAIN J.,
WALTERS WILLIAM A. W.
Publication year - 1986
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1986.tb07949.x
Subject(s) - hemodynamics , medicine , administration (probate law) , cardiology , political science , law
Summary. Serial haemodynamic and systolic time interval measurements in 17 male transsexuals during high‐dose oestrogen administration were compared with control values obtained after oestrogen withdrawal. During oestrogen treatment, cardiac output, stroke volume, plasma volume and total blood volume increased while total peripheral resistance, diastolic blood pressure and red cell mass decreased significantly. Changes in heart rate and systolic blood pressure were not significant. Despite a much higher dose of oestrogen, the haemodynamic changes observed in this study are similar in magnitude to those occurring in women taking oral contraceptives. Significant changes in systolic time intervals during oestrogen treatment were a shortened pre‐ejection period (PEP) index, a prolonged left ventricular ejection time (LVET) index and a decreased PEP/LVET ratio indicating that left ventricular performance was augmented.