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The actions of prostaglandins and their interactions with angiotensin II in the isolated perfused human placental cotyledon
Author(s) -
GLANCE D. G.,
ELDER M. G.,
MYATT L.
Publication year - 1986
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1986.tb07935.x
Subject(s) - cotyledon , angiotensin ii , chemistry , renin–angiotensin system , endocrinology , pharmacology , medicine , microbiology and biotechnology , biology , biochemistry , botany , receptor , blood pressure
Summary. The prostaglandins PGE 1 , PGE 2 , PGD 2 , PGF 2α ., U46619 and 6 β ‐PGI l were administered as bolus injections both separately and in combination with angiotensin II into the fetal circulation of isolated human placental cotyledons perfused in vitro . PGF 2α , and PGD 2 , caused small dosedependent increases in fetal perfusion pressure when compared with U46619 which acted as an extremely potent vasoconstrictor of the fetal‐placental vasculature. PGE 1 , caused very small dose‐dependent decreases in fetal perfusion pressure when injected on its own. In combination with angiotensin 11, PGE 1 , PGD 2 , and 6 β ‐PG1 1 , caused significant, dose‐related attenuations of the angiotensin II vasoconstrictive response whereas PGE 2 , PGF 2α , and U46619 potentiated the response. Injections of angiotensin II after the infusion of indomethacin into the fetal circulation resulted in a potentiation of angiotensin II induced vasoconstriction. The results indicate that prostaglandins exert their effects on the fetal‐placental circulation by modulating the actions of angiotensin II.