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The relation between plasma urate and placental bed vascular adaptation to pregnancy
Author(s) -
McFADYEN I. R.,
GREENHOUSE P.,
PRICE A. B.,
GEIRSSON R. T.
Publication year - 1986
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1986.tb07934.x
Subject(s) - pregnancy , medicine , uric acid , endocrinology , placenta , cardiology , obstetrics , fetus , biology , genetics
Summary. Placental bed biopsies were obtained at caesarean section from 34 women. Their plasma urate was directly related to maximum mean arterial pressure and inversely to adjusted birthweight; but it was related most closely to the histological appearances of the spiral arteries in the placental bed. Nine women had physiological changes in the spiral arteries: their mean urate (233, SD 28·9 μmol/l) was significantly ( P <0·00l) lower than the mean urate in those who did not have adequate physiological changes (339, SD 90·3 μmo1/l) or that in the nine women who had atherosis (397, SD 153·2 μmol/l). Raised plasma urate appears to be better related to maternal vascular pathology than to the clinical condition or infant birthweight.