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Immunosuppressive properties of pregnancy serum on the mixed lymphocyte reaction
Author(s) -
NICHOLAS N. S.,
PANAYI G. S.
Publication year - 1986
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1986.tb07860.x
Subject(s) - mixed lymphocyte reaction , pregnancy , lymphocyte , immunology , medicine , biology , immune system , t cell , genetics
Summary. The human fetus may escape immunological attack because of serum factors which have immunomodulatory influence on maternal cellular effector responses. Paired peripheral and retroplacental sera were shown to inhibit the allogenic mixed lymphocyte reaction (MLR) used as an in‐vitro model of cell‐mediated immunity. There was no correlation between the suppressive effect of the peripheral and retroplacental sera and the serum concentrations of four pregnancy‐related proteins (α‐fetoprotein, pregnancy‐associated α 2 glycoprotein, pregnancy‐associated plasma protein A and Schwangerschaftsprotein 1) to which immunosuppressive properties have been ascribed, but there was a negative correlation between peripheral AFP and MLR inhibition (r =−0·62, P < 0·001). Hence, the factor or factors responsible for suppressing the MLR are not those investigated in the present study.