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The significance of anti‐c alloimmunization in pregnancy
Author(s) -
BOWELL P. J.,
BROWN S. E.,
DIKE A. E.,
INSKIP M. J.
Publication year - 1986
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1986.tb07829.x
Subject(s) - pregnancy , obstetrics , medicine , biology , genetics
Summary. In an 8‐year period, 177 of 280 000 pregnancies were complicated by maternal anti‐c alloimmunization. Although there was one neonatal death associated with anti‐c haemolytic disease of the newborn, only two infants were severely anaemic at birth. A total of 11 babies required exchange transfusion, but nine of these developed hyperbilirubinaemia alone. The remaining c positive infants were either unaffected or only mildly affected by erythroblastosisfetalis. A strategy for management of these pregnancies is outlined, and proposed methods of prevention and serological control are discussed.