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Distribution of epithelial membrane antigen in normal and abnormal endometrial tissue
Author(s) -
MORSE ANNE R.,
CURRAN GEOFFREY J.
Publication year - 1985
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1985.tb04877.x
Subject(s) - pathology , hyperplasia , atypical hyperplasia , antigen , endometrium , adenocarcinoma , alkaline phosphatase , endometrial hyperplasia , biology , medicine , endocrinology , cancer , immunology , enzyme , biochemistry
Summary. The distribution of epithelial membrane antigen (EMA) on normal and abnormal endometrial tissue was studied as a method for distinguishing atypical hyperplasia from adenocarcinoma. Histological sections from 47 patients (nine adenocarcinoma, ninc atypical hyperplasia, nine cystic hyperplasia, 19 normal endomctrium and one sircoma) were studied with an immunocytochemical alkaline phosphatase technique that derrionstratcd EMA. At adilution of 1:1000 the majority of normal tissue was negative whereas all the abnormal tissue stained positively. At a slightly higher dilution all adenocarcinomas expressed thc antigen although only a few of the hyperplastic lesions (16%) stained with the antibody. The value of this approach for automated screening is discusscd.