Premium
Prevalence of human papillomavirus type 16 DNA sequences in cervical intraepithelial neoplasia and invasive carcinoma of the cervix
Author(s) -
McCANCE D. J.,
CAMPION M. J.,
CLARKSON P. K.,
CHESTERS P. M.,
JENKINS D.,
SINGER A.
Publication year - 1985
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1985.tb03019.x
Subject(s) - cervical intraepithelial neoplasia , cervix , human papillomavirus , medicine , koilocyte , genital warts , intraepithelial neoplasia , sex organ , pathology , cervical cancer , gynecology , cancer , biology , prostate , genetics
Summary. The frequency of human papillomavirus (HPV) type 16 in premalignant and malignant lesions of the cervix was investigated and compared with the detection of HPV type 6. In cervical intraepithelial neoplasia (CIN) grades I‐III HPV 6 was detected in 28% and HPV 16 in 62% of patients whereas 90% of malignant lesions contained HPV 16 only. In the CIN lesions there was an increase in HPV 16 detection as the severity of disease increased while the level of detection of HPV 6 decreased. Only three (18%) of the cervices that were colposcnpically and histologically normal contained HPV genomes: although two of these three women had either a history of genital warts or a sexual partner with penile warts.