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Natural history of cervical human papillomavirus (HPV) infections based on prospective follow‐up
Author(s) -
SYRJÄNEN K.,
VÄYRYNEN M.,
SAAKIKOSKI S.,
MÄNYJÄRVI R.,
PARKKINEN S.,
HTPPELÄINEN M.,
CASTREN O.
Publication year - 1985
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1985.tb03017.x
Subject(s) - colposcopy , medicine , natural history , carcinoma in situ , cervical intraepithelial neoplasia , cervix , concomitant , human papillomavirus , gynecology , group b , prospective cohort study , cervical cancer , biopsy , obstetrics , carcinoma , cancer
Summary. To assess the natural history of human papillomavirus (HPV) lesions in the uterine cervix, a prospective follow‐up of untreated lesions has been conducted since late 1981. The present report summarizes the data on 343 women with cervical HPV lesions currently followed‐up for a mean of 18.7 (SD 15.2) months by colposcopy and PAP smears (group R) or by additional punch biopsy (group A). Initially these tw7o groups were classified on the first PAP smears, presenting with HPV‐induced cytopathic changes, and either with (group A) or without (group B) concomitant changes suggestive of cervical intraepithelial neoplasia (CIN). The clinical course of the HPV lesions could not be predicted adequately from the findings of the first PAP smears, as evidenced by the higher progression rate (154%) in the 214 women initially classified in group B, compared with 116% in the 129 women classified in group A. Furthermore, the number progressing to careinomia in situ requiring conization was equal (seven patients) in the two groups. This necessitated a more flexible approach to follow‐up, permitting transfer of patients between groups, which resulted in a final allocation of 261 women to group A, and 82 to group B. To date, 25% of the total of 343 HPV lesions have regressed. 61% have persisted, and 14% have progressed. Of the latter, a total of 14 (4.1%) have been coned due to progression to carcinoma in situ . The rate of regression seems to be inversely related, and progression directly related. to the degree of HPV‐associated CIN. The results are discussed in the light of the well‐established natural history of classical CIN. Generally recognized as premalignant tesions. The present results, demonstrating that the natural history of cervical HPV lesions is very similar to that o f CIN, further substantiate the concept of HPV lesions as precursors of cervical cancer. With the potential to progress to carcinoma in situ when left untreated.