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Assessment of bleomycin, adriamycin and mitomycin‐C in the treatment of recurrent cervical cancer
Author(s) -
MEANWELL CLIVE A.,
LUESLEY DAVID M.,
BLACKLEDGE GEORGE,
MOULD JOHN J.,
CHAN K. K.,
PERREN TIMOTHY J.,
LAWTON FRANK G.
Publication year - 1985
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1985.tb01461.x
Subject(s) - bleomycin , complete response , medicine , cervix , mitomycin c , radiation therapy , chemotherapy , basal cell , cancer , toxicity , oncology , progressive disease , cervical cancer , gastroenterology , surgery
Summary. Twenty women with recurrent squamous cell carcinoma of the cervix were treated with bleomycin followed by adriamycin and mitomycin‐C. Treatment was repeated every 28 days. In 18 patients who could be assessed there was one complete response and five partial responses (response rate 33%). Two partial responses were seen in 13 lesions arising from previously irradiated sites of disease (response rate 23%). Three complete responses and three partial responses were observed in 10 lesions arising from non‐previously irradiated sites of disease (response rate 60%). In all responding cases tumour regression was noted before the end of the third cycle of treatment. Toxicity was predictable and manageable. These results suggest that chemotherapy may be used as a cytoreductive procedure before radical local treatment.