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Increased sensitivity to thromboplastin synthesis in blood monocytes from pre‐eclamptic patients
Author(s) -
ØIAN PÄL,
OMSJØ IVAR,
MALTAU JAN MARTIN,
ØSTERUD BJARNE
Publication year - 1985
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1985.tb01357.x
Subject(s) - thromboplastin , medicine , partial thromboplastin time , endocrinology , fibrinogen , normal group , prothrombin time , prekallikrein , tissue factor , eclampsia , factor vii , pregnancy , coagulation , chemistry , biology , enzyme , kallikrein , biochemistry , genetics
Summary. The thromboplastin activity in blood monocytes was investigated in third‐trimester pregnancies comprising 11 patients with severe pre‐eclampsia, 10 with essential hypertension and 18 normal pregnancies. Thromboplastin activity in unstimulated monocytes from the severe pre‐eclamptic group was on average three times that found in the normal pregnant group, but variation was wide and the differences were not statistically significant. Thromboplastin activity in endotoxin‐stimulated monocytes was significantly higher in the severe pre‐eclamptic group than in the other two groups (normal and chronic hypertensive). In the severe pre‐eclamptic group, there was a significant negative linear correlation between thromboplastin activity of the endotoxin‐stimulated monocytes and factor VII. Fibrinogen, factor VII and α 2 ‐antiplasmin were significantly lower in the severe pre‐eclamptic group than in the normal pregnant group, whereas no differences were observed in factors V, VIII, AT‐III and prekallikrein.